I was blown away last month by a piece of cloud software called iPlotz. This subscription service allows you to draw out sketches of the website you are planning, with tools I have only normally expected with desktop applications. Within one afternoon I had created a template of my header, footer and content sections of a site, which I then individualised for the different pages and content areas of the site.
The programme is incredibly intuitive, allowing you to drag and drop fake images and videos directly onto the page. At the end of the process you can even export the whole project as HTML so you can show colleagues or clients how the site is likely to look.